Everyday movement
Walking, stairs or standing for longer periods are becoming uncomfortable. Bring examples of what you would like to do more easily.
Reviewed byProfessor Paul YF Lee MBBch, FRCS (Tr & Orth), PhDCartilage and joint preservation expertiseIf knee osteoarthritis is still affecting daily life despite treatment, Arthrosamid may be an option to explore. An assessment helps establish whether it suits your knee and your goals.
A starting point for discussion; suitability is confirmed in consultation.

Walking, stairs or standing for longer periods are becoming uncomfortable. Bring examples of what you would like to do more easily.
You have tried appropriate exercise, physiotherapy or other care, but symptoms persist. Your clinician will review what you have tried and discuss the next options.
You are considering an injection and want to understand how it works, what it involves and where it fits into your wider treatment plan.
We bring your symptoms, scans and goals together to explain which options fit your knee.
Where it hurts, how long it has troubled you and what limits your day.
The pattern of osteoarthritis and other possible causes of pain.
What you have tried and how your knee responded.
Your medical history, medicines and any infection concerns.
The activities and priorities you want your care to support.
A clear explanation of your options and what happens next.
BEHIND YOUR RECOMMENDATION
Recent X-rays and, where available, MRI help us assess the stage and pattern of wear, alignment and other possible sources of pain. Tell us which treatments you have tried and what changed: physiotherapy, activity modification and simple pain relief remain important foundations.
We review medicines and medical conditions, including anticoagulation, diabetes control, immunosuppression and recent infection. These may change the treatment plan or timing. Your examples of pain, limitations and goals help us judge whether the likely benefit matches what matters to you.
For adults with diagnosed knee osteoarthritis, Arthrosamid may be considered when symptoms continue despite appropriate conservative care. If your pain and stiffness are limiting your daily life and you are looking for a non-surgical option to help manage these symptoms, your assessment will help establish whether it fits your needs.
Another cause of knee pain may require entirely different treatment. Advanced joint changes, marked deformity, or instability may prompt a discussion about surgery instead. Additionally, any active infection needs addressing before an injection can be safely considered.
THE WHOLE PICTURE

01 / Your knee
A clinical diagnosis supported by recent imaging (X-ray or MRI). The diagnosis matters because Arthrosamid® is licensed and evidence-based specifically for osteoarthritis, not general knee pain.
Stage is considered alongside symptoms, alignment, stability and function. The observational evidence does not turn a wear grade into an individual response prediction.

02 / Your everyday life
You have tried activity modification, physiotherapy and simple pain relief, and symptoms continue to limit daily activity. Arthrosamid® is generally not a first-line option.
Arthrosamid may be discussed as symptom management, but it has not been proved to delay knee replacement. Significant pain, deformity or loss of function may make surgical assessment more appropriate.
03 / Your treatment plan
Understanding that Arthrosamid® is intended for symptom management, not as a cure or cartilage-regeneration treatment. The observational cohort reports group outcomes through 24 months, not a guaranteed response or duration.
Comfortable with our conservative protocol including ultrasound-guidance, IV antibiotic cover and the six-week follow-up. Skipping safety steps to save cost is not an option we offer.
WHEN WE PAUSE AND PLAN
Some factors call for extra planning; active infection is a reason to defer treatment. We review each of the following before recommending a pathway.
End-stage osteoarthritis where the joint surface has been substantially lost. Arthrosamid® may give some relief but the underlying disease may progress to needing knee replacement.
Any active infection, in the joint or systemically, is a reason to defer Arthrosamid®. We treat the infection first.
Raised HbA1c increases infection risk for any joint injection. We may ask you to optimise control before scheduling.
Patients on immunosuppressive therapy or with conditions that raise systemic infection risk warrant a tailored discussion.
Patients who expect Arthrosamid® to cure their arthritis, regenerate cartilage or guarantee permanent relief are not good candidates — the treatment cannot deliver any of those things.
A clinic-specific safety protocol that includes IV antibiotics, sterile technique and six-week follow-up is non-negotiable at London Cartilage Clinic. If these steps are a concern, discuss other treatment options with the team.

CHOOSING THE RIGHT PATH
Bone-on-bone arthritis needs an individual assessment. A hydrogel acting on the joint lining cannot replace lost joint surfaces. Imaging, pain, alignment, stability and daily function help determine whether an injection or a knee-replacement opinion is more appropriate.
In these cases, the better answer is often a knee replacement conversation. We will say so honestly. Read more on the Arthrosamid® vs knee replacement comparison.
Where the disease is moderate but advancing, Arthrosamid® may still be appropriate as a symptom-management option. It is not proved to delay surgery. Imaging and clinical assessment help decide whether an injection or replacement opinion is the more appropriate discussion.
The assessment brings together your medical history, imaging, and personal goals to provide a clear explanation of your options. Coming prepared helps us focus on what matters most.
A starting point for discussion; it does not replace a clinical assessment.
This short questionnaire organises relevant questions before assessment. It does not diagnose osteoarthritis, apply group evidence as an individual prediction or confirm suitability. Use it to prepare for a clinical conversation.
The ideal candidate is an adult with a clinical and imaging diagnosis of knee osteoarthritis, ongoing symptoms despite appropriate conservative treatment, realistic expectations and no contraindication. Current imaging, stage, alternatives and willingness to accept the product-specific safety protocol all form part of the decision.
That description does not predict whether Arthrosamid will work. Advanced disease, deformity, instability or major functional loss should prompt a balanced knee-replacement assessment. We review imaging and the clinical picture rather than using one label alone.
Well-controlled diabetes is not a contraindication, but poorly controlled diabetes raises the infection risk for any joint injection. We will review HbA1c and recent control as part of the assessment, and may ask you to optimise control before scheduling treatment.
Treatment may be possible, but the decision depends on the medicine, why it was prescribed and your bleeding and clotting risks. Do not stop it yourself. We review this at consultation and may ask the prescribing clinician to advise on peri-procedure management.
A borderline score on the Arthrosamid® suitability self-assessment is one of the reasons we offer a free discovery call before committing to a consultation. The questionnaire is a decision-support tool, not a final answer; the consultation is where the clinical decision is made.
Yes. We do not recommend Arthrosamid® where the indication is absent, a contraindication is present or another treatment is more appropriate. See the Arthrosamid® safety page for the broader picture.
Learn more about what to expect from treatment, dive into the research, or see how it compares to other options.
Understand the recovery timeline and returning to activity.
Explore published evidence and patient outcomes.
Compare approaches to help guide your decision.
Talk through your symptoms, goals, and treatment options with the team.