6.64→5.06
Less pain on average
Pain score out of 10. A lower score means less pain.
Arthrosamid® knee injection
Less knee pain. More everyday life.
A non-surgical injection that can help ease the pain and stiffness of knee osteoarthritis. Explore whether Arthrosamid could help you move more comfortably.
Treatment with Professor Paul YF Lee · 66 Harley Street, London
Who it is for
Knee osteoarthritis
Treatment
Outpatient injection
Recovery
Rest, then gradual return
Treatment cost
From £3,000
Consultation £350 separately
Could Arthrosamid help your knee?
If arthritis makes walking, stairs or everyday activities uncomfortable, Arthrosamid may be an option to discuss—particularly when exercise, physiotherapy or pain relief have not given you enough improvement.
IS THIS YOUR STARTING POINT?
When to consider an assessment
These are reasons to start a conversation with the team. The assessment helps establish what is causing your symptoms and which options fit your knee.
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Daily life is becoming harder
Pain or stiffness affects walking, stairs or your daily routine.
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You want to explore a non-surgical option
You want to understand whether an injection has a place in your treatment plan.
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Other care has not helped enough
You have tried care such as exercise, physiotherapy or pain relief and want to discuss what comes next.
A starting point for discussion, not a diagnosis or confirmation of suitability.
Your symptoms, examination, scans and medical history guide the recommendation. Advanced arthritis, knee instability or an active infection may change which treatment is appropriate.
What is Arthrosamid?
Arthrosamid is a soft, non-absorbable polyacrylamide hydrogel injected into the knee. It integrates into the synovium, the lining of the joint capsule, rather than acting as a cushion between the bones. It is used to manage osteoarthritis symptoms; it does not rebuild cartilage or cure arthritis.
Your treatment, step by step
1. Consultation
Review your symptoms and examine your knee. Submit existing scans through the patient portal beforehand.
2. Treatment day
Ultrasound-guided injection with local anaesthetic and IV antibiotics for every Arthrosamid treatment.
3. Home the same day
Written aftercare and team contact details provided.
4. Follow-up
Review of your progress at around six weeks.
Getting back to your routine
Your individual aftercare instructions guide your return to work, driving and exercise.
First 24 hours
Plan relative rest.
First 72 hours
Avoid strenuous activity.
Following weeks
Build activity gradually.
Around 6 weeks
Review your progress.
Research behind your treatment
Research and results
The 2025 study followed 269 patients with knee osteoarthritis for two years. On average, patients reported less pain and better knee function at 24 months than before treatment.
Explore the research and results
269Study participants
24Months of follow-up
Prospective observational cohort study
What changed at two years?
Published group averages · before treatment → 24 months
25.35→31.95
Daily activities became easier
Oxford Knee Score. A higher score means better pain and function.
45.22→56.15
Better overall knee scores
Lysholm score. A higher score means fewer symptoms and better function.
These improvements support discussing Arthrosamid as a symptom-management option. They do not mean everyone improved or became pain-free. Some patients still needed knee replacement.
This observational study had no comparison group, so it cannot establish how much improvement was caused by the injection. Your response and the duration of any relief may differ. See the full findings, safety results and study context →
Explore your options
How does it compare?
The right choice depends on your knee, the relief you need and your recovery priorities.
Arthrosamid vs
PRP
Compare treatment approaches
Arthrosamid vs
Steroid injection
Compare their different roles
Arthrosamid vs
Hyaluronic acid
Explore another injection option
Arthrosamid vs
Knee replacement
Understand when surgery may be discussed
Explore all alternatives, including exercise and physiotherapy
MORE THAN THE INJECTION
Are all Arthrosamid injections the same?
Professor Lee explains how assessment, sterile preparation, ultrasound guidance and aftercare contribute to your treatment.
Side effects and safe care
Temporary soreness, swelling or stiffness can follow treatment. Joint infection is a serious possible complication. We use sterile technique, ultrasound guidance and IV antibiotics, and explain when to contact the team afterwards.
Clear costs. Planned care.
From £3,000 / one box
The amount required is confirmed after assessment. Includes ultrasound, Arthrosamid product, procedure, IV antibiotics and six-week follow-up.
Consultation with Professor Lee £350 separately. MRI and onward physiotherapy charged separately if required.
Your care at London Cartilage Clinic
Professor Paul YF Lee
Consultant Orthopaedic Surgeon
Consultant-led assessment and treatment, with a plan built around your knee and the activities that matter to you.
66 Harley Street, London
1,200+Arthrosamid injections performed at the clinic
As of August 2026 · injections, not individual patients
YOUR QUESTIONS, ANSWERED
A little clarity before your next step.
Start with the questions patients often ask. Our full guide goes further into treatment, results and everyday practicalities.
Explore all Arthrosamid FAQs01How long might the benefit last?
Published research has followed patients for 24 months. That describes the study period, not a guaranteed duration of relief. Your response and progress are reviewed individually. Explore the research and results.
02Can I have Arthrosamid with bone-on-bone arthritis?
The scan description alone does not decide suitability. Your pain, movement, knee stability and goals all matter. Your clinician will discuss whether an injection or another option, including surgery, better fits your knee. Read about suitability.
03Will I need time off work or driving?
Plan an initial quiet period. Returning to work depends on the demands of your role. Drive only when you can safely control the vehicle and perform an emergency stop, without impairment from pain or medicines. See the practical aftercare guide.
04What is the difference between a discovery call and a consultation?
The free discovery call is an introductory conversation with the clinic team. The £350 consultation with Professor Lee is a clinical assessment of your knee, scans and treatment options. You can also start with the suitability self-assessment.
Let’s find the right next step for your knee.
Start with a free introductory call with our team, or book a clinical assessment with Professor Lee.